Obstructive sleep apnoea (OSA) negatively impacts various domains including quality of life, productivity, alertness, activity levels, social interactions and sexual health (Weaver & George, 2011). Clinically, OSA features recurrent upper airway collapses (i.e. obstructive hypopneas and apnoeas) with intermittent hypoxemia, leading to frequent arousals, potential slow-wave sleep reduction, and/or rapid eye movement sleep depletion, and increased light sleep proportions (Barner et al., 2016). OSA-related sleep disruptions also impact cognitive functions (Luz et al., 2016; Wallace & Bucks, 2013). Verbal memory deficits, in particular, have been reported in OSA (Kloepfer, 2009), other reports additionally suggesting visuospatial episodic memory (Wallace & Bucks, 2013) and implicit sequence learning (Csábi et al., 2014) deficits. Conversely, there is limited evidence for memory improvement (Zimmerman et al., 2006; Sforza & Roche, 2012) after continuous positive airway pressure (CPAP) treatment. This treatment operates as a pneumatic splint that sustains the upper airway opening by delivering constant positive air pressure through a mask (Deacon et al., 2016). Its use has been proven to significantly lessen the apnea-hypopnea index (AHI), an average joined count of respiratory events (apneas and hypopneas) developing per hour of sleep (Pavwoski & Shelgikar, 2017). It is currently considered the first-line, gold standard treatment for moderate (15 < AHI < 30) and severe (AHI > 30) OSA (Rotenberg et al., 2016) and can also be adapted to mild but symptomatic cases (Buchanan & Grunstein, 2011). CPAP has been shown to overcome sleep-related symptoms and increase quality of life (Laratta et al., 2017). Cognitive functions, e.g., visual (Lin et al., 2015) and short-term memory (Canessa et al., 2011), seem to be partially restored by standard OSA treatment such as positive airway pressure (PAP), but the reversibility of OSA-related deficits in verbal memory following PAP treatment needs to be further investigated.
Impaired sleep quality is detrimental to verbal memory, both at encoding after disrupted sleep or during memory consolidation as tested after post-learning sleep (Rasch, & Born, 2013). In healthy subjects, prior sleep quality is associated with verbal memory performance (Cipolli, Mazzetti, & Plazzi, 2013). In chronic sleep disorders such as OSA, sleep alterations may be detrimental to memory encoding (for a review, see Cipolli, Mazzetti, & Plazzi, 2013). Besides, it is possible to delineate altered verbal memory components by distinguishing between recalling a memorized item and its shallower integration into semantic memory. According to the dual-process Fuzzy-Trace Theory (FTT) model (Brainerd & Reyna, 1998), word recognition involves the simultaneous memorisation of the general idea to which it refers, in other terms its “deep” meaning (Gist memory) but also the specificity of this word (Verbatim or item-specific memory). Therefore, the representation of the word is not memorized as a single entity. Rather, there is parallel encoding with separate storage of Gist and Verbatim traces, that could be separately activated. In this framework, the memory illusion eventually leading to a false memory may result either from the recovery of the representation of the general idea of the words in the learning list rather than from their specifics, or from the recovery of an erroneous Verbatim trace. Exact memory would be subtended by the recovery of a correct Verbatim trace. The formation of false memories has been mainly studied using the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995). In the DRM procedure, participants are first asked to memorize lists of words (e.g., a list with the words “trunk”, “branch”, “leaf”, “wood”, “roots”, “fir oak”, “strain”, “lumberjack”…). They are not informed that all words in a learning list are actually semantically linked to the same semantic field (“tree” in the present example) which is not presented in the list of words to remember. In this framework, considering that a new word (e.g., “trunk”) is not only memorized as a specific item but also integrated into the related existing semantic networks (e.g., “tree”), this normal integrative mechanism may paradoxically lead to a so-called false memory effect. Indeed, when presented with semantically related but unstudied elements (e.g., the word “tree”), participants will tend to erroneously recognize the new item as previously learned (Arndt, 2012), besides correctly recognizing the studied ones. Critical lures and words presented within the studied list were shown recognized at a similar rate (e.g., 55%; Roediger & McDermott, 1995), and up to 70% of semantically associated words may be falsely recognized as previously learned (Payne et al., 1996; De Brigard, 2014). Consequently, it can be argued that the production of semantically related (but false) memories reflect normal integration mechanisms in human memory (Schacter, Guerin, & St Jacques, 2011; Pardilla-Delgado & Payne, 2017).
In this context, patients with OSA were shown to exhibit poorer discrimination than healthy controls when facing a forced-choice recognition between previously learned words (e.g. “trunk”) and the critical lure (e.g., “tree”), but to achieve similar performance levels when memory performance could be based on Gist information (e.g., “trunk” vs “piano”; Sarhane et al., 2014). It suggests that patients with OSA mostly stored the general idea (gist) of the learned information but were less efficient with the item-specific (verbatim) memory. Memory deficits in OSA appear to be most important when patients must recollect specific details of the learning episode (e.g., item’s specific context or source; Sarhane & Daurat, 2017). Consequently, recollection deficit in OSA patients would eventually lead to higher and easier acceptance in a recognition task of novel items when they are conceptually related to previously learned items. However, this interpretation might be disputed based on prior findings. Indeed, it was shown that the susceptibility to memory illusions (as investigated with the DRM paradigm) tends to increase with age (Dehon, 2006; Dehon & Brédart, 2004; Butler, 2004). Accordingly, a meta-analysis of 232 studies reported better performance in recognition tasks in young than in older adults, the latter having a propensity bias for more liberal answering eventually leading to an increment in false alarms (Fraundorf et al., 2019; Sejunaite et al., 2019). The facts that verbal memory difficulties in patients with OSA can be seen as equivalent to those experienced by healthy controls 10 years older (Twigg et al., 2010) and/or that age-related heterogeneity is higher for item-specific than gist-based memory tasks (Brainerd & Reyna 2005, in Latour, Latour, & Brainerd, 2014) may explain the reported dissociation between item-specific and gist memory in patients with OSA (Sarhane et al., 2014). Additionally, increased susceptibility of patients with OSA to false recognition may stem from a limited availability of attentional resources eventually disrupting recovery processes (Sarhane & Daurat, 2019). This is in line with prior reports showing that young adults achieve similar performance levels than older adults when cognitive resources are reduced at encoding (Dehon 2006),
In this framework, the present study aimed at investigating immediate and delayed CPAP treatment-related effects on verbal memory integration in OSA. Participants with OSA were tested using a controlled semantic memory paradigm aimed at inducing false memories (DRM; Deese, 1959a; Roediger & McDermott, 1995), first in an untreated condition then immediately after PAP initiation, and after three months of PAP compliant use. We expected PAP treatment to increase overall episodic memory performance, both for the recall of learned (exact) words and the integration of non-learned but semantically related words (i.e., “false” memories).
23 French-speaking male participants (55.39 ± 8.92 years) gave written informed consent to participate in this study approved by the Brugmann Hospital Ethics committee (CE 2016/86). Inclusion criteria were PSG-based OSA diagnosis and an obstructive apnoea-hypopnea index (OAHI) > 15/hour during sleep. From this cohort, 12 patients (55.25 ± 10.17 years) were tested three months later (average PAP compliance 5.1h/24h ± 0.37 during the three months period). At enrolment in the protocol, exclusion criteria were PAP treatment prior to the study, neurological or psychiatric comorbid conditions, history of opioid treatment or current benzodiazepine intake. Participants were also asked to avoid stimulating and/or alcoholic drinks the day before as well as during the experimental days. For the 12 participants tested three months later, the inclusion criterion was to sleep at least five days a week for at least four hours per night under fixed air pressure administration from the introduction of the PAP treatment to the follow-up session.
Upon admission to the Sleep Laboratory, before the polysomnography (PSG) diagnosis night, participants were administered a battery of psychometric instruments, including the Morningness-Eveningness questionnaire (MEQ, circadian typology; Ogiska, 2011), the Pittsburgh Sleep Quality Index (PSQI, sleep quality of the previous month; Buysse et al., 1989), the fatigue severity scale (FSS, perceived impact of fatigue on the previous month; Krupp et al., 1989), the Brugmann Fatigue Scale (BFS, the behavioral impact of physical and mental fatigue; Mairesse et al., 2017), the Epworth Sleepiness Scale (ESS, sleep propensity in specific situations; Johns, 1991) and the hospital anxiety and depression scale (HADRS; Zigmond & Snaith, 1983). To control for verbal abilities, phonological and categorical fluency tasks (Cardebat et al., 1990) were administered: participants had to produce as many different words as possible within one minute, either starting with the same phoneme (P; phonological) or belonging to the same semantic category (animals; categorical). Additionally, they completed the Mill-Hill Vocabulary Scale Part B (Deltour 1993), in which a synonym must be selected out of 6 propositions for 33 different words of increasing complexity. Cut-offs were not used for inclusion-exclusion of the participants, these tests aiming for a clinical characterization. As the experimental task was verbal (see below), screening for participants’ French fluency was conducted informally by the main experimenter as an interview with each participant when explaining the modalities of the experiment.
In the morning following their first night in the sleep unit and after confirmation of the OSA diagnosis, patients completed the St-Mary’s Sleep Questionnaire (Ellis et al., 1981) subjectively assessing the quality of the preceding night. They then underwent a first experimental session in the sleep laboratory. During this session, they were administered (1) the learning phase of the DRM (see below; Deese, 1959a; Roediger & McDermott, 1995), (2) a 10-minute version of the psychomotor vigilance task (PVT; Basner et al., 2015) and (3) the test phase of the DRM. Sleepiness (Babkoff, Caspy & Mikulincer, 1991), fatigue (Lee et al., 1991), and mood (Nyenhuis et al., 1997) scales were administered before and after each phase.
During the subsequent PSG night in the sleep laboratory, CPAP was initiated, and adequate air pressure titrated. A second experimental session (identical procedure) was held the following morning. Finally, a third experimental session (identical procedure) was held three months later (without PSG recording).
The DRM (Deese, 1959a; Roediger & McDermott, 1995) is a paradigm aimed at inducing false memories using a controlled material. In the learning phase of each experimental session, 10 separate lists of words were orally presented to the participants who were asked to carefully listen and memorize. The words were uttered by a recorded female voice at a one-word-per-second frequency, with at least a 10-second break between every list. Each list included 15 items semantically related to a theme (or lure) word not included in this list (e.g. “trunk”, “branch”, “leaf”, “wood”, “roots”, “fir oak”, “strain”, “lumberjack”… related to the word “tree”). Ten different lists were presented at each session, out of a choice of 30 different lists previously shown to be comparable in terms of saliency and frequency of appearance of the words (Darsaud et al., 2011; Schmitz, Dehon, & Peigneux, 2013). It should be noticed that while the DRM task here is similar to the one used by Darsaud et al. (2011) who aimed at investigating sleep-dependent memory consolidation effects, we focused here on the effect of prior sleep quality on verbal memory performance with a limited time interval between the learning and recognition phases. Results will thus not be comparable.
During the test phase following the PVT, participants had to identify the previously studied words within a list of 60 words successively displayed on the computer’s screen. The testing material included 20 studied items, 10 lures (i.e., non-studied but semantically related theme words), and 30 distractors (unrelated, non-studied words). Those distractors englobed 10 distractors matched with lures, and 20 distractors matched with studied items, in terms of gender, grammatical class, number of syllables, frequency, and the absence of semantical association to the studied words or between them (see Dehon & Brédart, 2004, for a detailed presentation of the material). The 20 studied items were the first and the twelfth of each studied list. Prior DRM experiments using a recognition testing modality also presented studied words at precise n position of the studied list (e.g., positions 1, 8, and 10 in Roediger & McDermott, 1995) to test for the degree of semantic association effects, the words in a list being ordered from the highest to the lowest semantic association strength with the lure. To the best of our knowledge, similar memory performance was found in all of these studies, suggesting that participants do not take advantage of the correlation between item position and presence in the testing material.
When a word was recognized as studied, participants were asked to specify whether their recognition was based on a clear memory recollection of the studied word (Remember), a feeling of familiarity about the word (Know), or if their response was at random (Guess) (Gardiner, Ramponi, & Richardson-Klavehn, 1998). The experiment was implemented using Cogent 2000 (http://www.vislab.ucl.ac.uk) running on Matlab R2014a.
At the beginning of each experimental session, three visual analog scales (VAS) were administered. The first assessed the perceived level of sleepiness (VAS-S; Babkoff, Caspy, & Mikulincer, 1991), the second evaluated subjective fatigue (VAS-F; Lee et al., 1991), and the third assessed subjective mood (VAS-M; Nyenhuis et al., 1997). At each session, participants completed the scales three times (after DRM learning, after PVT, and after DRM recognition).
The 10-min version of the computerized Psychomotor Vigilance Task (PVT; Basner et al., 2015) was also administered. In this task, patients had to press a key as fast as possible as soon as a 1 msec incrementing counter appears on-screen. Stimuli were displayed at intervals ranging randomly from 2, 4, 6, 8, and 10 sec.
Clinical PSG recordings were conducted using standard guidelines defined by the American Academy of Sleep Medicine (AASM, 2014), including high-resolution infrared videography. PSG recordings included at least Fp2-Ax, C4-Ax, and O2-Ax derivations, two electrooculograms, anterior and bilateral anterior tibial electromyograms. Oral and nasal airflow was recorded by an oro-nasal cannula (Pro-Flow Plus™ Pro-Tech® Mukilteo, WA, USA). Respiratory effort was measured by thoracic and abdominal belts (Pro-Tech® CT2™, Mukilteo, WA, USA). Capillary oxygen saturation was monitored by photo-oximetry (Nonin® Flexi-Form® II 7000A Nonin Medical Inc., Minneapolis, MN, USA et LINOP® Adt Masimo corp. Irvine, CA, USA). All PSG recordings were analyzed on 21” screens with epochs of 30-second polysomnography (Philips Respironics Inc™ Alice6®, Philips Healthcare™, Eindhoven, NL, EU) by qualified technicians unaware of the objectives of the study. PAP-devices were Auto-Continuous PAP (automatic pressure titration) DreamStation® (Philips Respironics Inc™).
Statistical analyses were performed using IBM SPSS 25® (International Business Machines, SPSS™, Armonk, NY, USA). Immediate and sustained treatment effects were investigated using Linear Mixed Models with time as the fixed effects and subjects as the random effects. Models were estimated through Restricted Maximum Likelihood with a First-Order Autoregressive (AR1) covariance structure. Distractor-related responses were subtracted from true and false memory data to obtain induced-memory scores purged from intrusions. Pearson correlations were performed on memory data and sleep parameters before and after PAP-treatment.
Demographic variables and scores measured at enrolment are reported Table 1, both for the 23 participants having participated to the first and second experimental sessions (two successive days), and for the subsample of 12 having participated to the third experimental session 3 months later.
|ORIGINAL SAMPLE (S1–S2)||RANGE S1–S2||FOLLOW–UP SAMPLE (S3)||RANGE S3|
|Age||55.95 (9.15)||42–73||55.25 (10.17)||42–73|
|PSQI||8.21 (4.06)||2–16||7.73 (4.92)||2–16|
|ESS||8.65 (4.65)||3–20||9.17 (4.90)||3–20|
|FSS||3.76 (1.87)||1,22–7||3.85 (1.98)||1,22–7|
|Mental BFS||3.55 (2.69)||0–9||1.5 (0.25–3)||0–8|
|Physical BFS||4.3 (2.66)||0–10||3.5 (2.20)||0–8|
|Morningness-Eveningness scale||21.5 (8.61)||12–40||20 (7.19)||12–32|
|Distinctness scale||17.10 (7.21)||6–30||16 (8)||6–30|
|HADS Total||12.45 (5.79)||3–28||12.08 (6.68)||3–28|
|HADS Anxiety||6.5 (3.46)||2–15||6.08 (3.61)||2–15|
|HADS Depression||5.95 (3.66)||1–13||6 (3.98)||1–13|
|Mill Hill||21.57 (6.82)||4–33||23.58 (5.14)||14–33|
|Phonological fluency||22.20 (6.98)||13–38||21.08 (7.38)||13–38|
|Semantical fluency||26.29 (6.51)||15–38||27.25 (6.06)||18–36|
|Reciprocal reaction time (PVT)||3.03 (.26)||2.48–3.46||3.02 (0.20)||2.71–3.34|
Subjective sleep satisfaction (Ellis et al., 1981) improved after the first night of CPAP (n = 23; all p’s < .05). Subjective sleep parameters (Ellis et al., 1981) improved in all domains after three months of compliant use (n = 12; all p’s > .05; see Table 2).
|BASELINE (S1)||CPAP TRIAL (S2)||FOLLOW-UP (S3)||S2–S1||S3–S1|
|M (SD =)||M (SD =)||M (SD =)|
|Sleep depth||4.09 (.33)||4.63(.35)||6.42 (.47)||Δ = .55; p = .18||Δ = 2.33; p < .001|
|Sleep quality||2.78 (.24)||3.25 (.25)||4.97 (.35)||Δ = .47; p = .16||Δ = 2.18; p < .001|
|Sleep satisfaction||2.44 (.23)||3.12 (.24)||4.01 (.33)||Δ = .68; p = .03||Δ = 1.57; p < .001|
|Nocturnal awakenings||2.78 (.35)||2.70 (.36)||.51 (.48)||Δ = –.09; p = .82||Δ = –2.28; p < .001|
|Perceived difficulty of falling asleep||1.83 (.15)||2.04 (.16)||.84 (.21)||Δ = .21; p = .26||Δ = –.99; p < .001|
All polysomnographic parameters improved from baseline to the first night when PAP treatment was initiated (see Table 3).
|BASELINE||CPAP TRIAL||BASELINE VS. CPAP TRIAL NIGHT||DIRECTIONALITY|
|M (SD)||M (SD)||F, P|
|TIB||515.75 (7.47)||510.26 (7.47)||F(1,22) = .83 p = .37||S1 = S2|
|TST||357.41 (15.93)||346.94 (15.93)||F(1,22) = .39 p = .54||S1 = S2|
|SPT||424.33 (15.43)||411.74 (15.43)||F(1,22) = .74 p = .4||S1 = S2|
|Sleep efficiency||68.95 (2.55)||67.7 (2.55)||F(1,22) = .20 p = .66||S1 = S2|
|Total number of Arousals||241.59 (15.86)||113.68 (15.86)||F(1,21) = 57.96 p < .01||S1 > S2|
|Snore (%)||36.51 (4.10)||11.26 (4.10)||F(1,22) = 33.06 p < .01||S1 > S2|
|N1 (%)||18.25 (1.99)||13.97 (1.99)||F(1,22) = 4.23 p = .05||S1 > S2|
|N2 (%)||52.10 (2.83)||48.33 (2.83)||F(1,22) = 1.25 p = .28||S1 = S2|
|N3 (%)||17.08 (2.25)||19.99 (2.25)||F(1,22) = 1.23 p = .28||S1 = S2|
|REM (%)||12.57 (1.19)||17.72 (1.19)||F(1,22) = 16.93 p < .01||S1 < S2|
|AHI (/h)||39.9 (3.08)||10.14 (3.08)||F(1,22) = 73.53 p < .01||S1 > S2|
|AHI REM (/h)||33.74 (3.30)||6.97 (3.30)||F(1,22) = 38.62 p < .01||S1 > S2|
|AHI NREM (/h)||40.44 (3.33)||10.95 (3.33)||F(1,22) = 63.78 p < .01||S1 > S2|
|OAHI (/h)||37.31 (3.13)||8.26 (3.13)||F(1,21) = 66.10 p < .01||S1 > S2|
|RDI (/h)||45.1 (3.02)||12.19 (3.02)||F(1,21) = 99.59 p < .01||S1 > S2|
|RDI REM (/h)||37.54 (3.46)||8.39 (3.46)||F(1,22) = 37.66 p < .01||S1 > S2|
|RDI NREM (/h)||45.60 (3.12)||13.17 (3.12)||F(1,22) = 95.93 p < .01||S1 > S2|
|ODI (/h)||27.06 (3.53)||7.02 (3.53)||F(1,22) = 28.58 p < .01||S1 > S2|
|Mean Saturation||27.05 (3.53)||7.02 (3.53)||F(1,22) = 28.58 p < .01||S1 > S2|
|ArI Total||241.59 (15.89)||113.68 (15.89)||F(1,21) = 57.96 p < .01||S1 > S2|
|ArI respiration||27.52 (4.2)||9.48 (4.2)||F(1,22) = 11.70 p = .02||S1 > S2|
|ArI Desaturation||96.87 (10.59)||15.65 (10.59)||F(1,22) = 42.76 p < .01||S1 > S2|
Subjective evaluations (visual analog scales) remained stable throughout the three sessions for sleepiness (sleepiness at the first session = 3.98 ± .5, sleepiness at the second session = 3.80 ± .52, sleepiness at the last session = 2.61 ± .68; F(2, 31.82) = 1.65, p = .21), fatigue (fatigue at the first session = 4.54 ± .47, fatigue at the second session = 4.16 ± .49, fatigue at the last session = 2.85 ± .65; F(2, 32.65) = 2.41, p = .11) and mood (mood at the first session = 7.97 ± .5, mood at the second session = 7.82 ± .51, mood at the last session = 6.79 ± .63; F(2, 29.09) = 1.81, p = .18).
Likewise for the PVT, evaluation of reciprocal reaction time (RRT (Basner et al., 2015)) with Session as the within-subject factor (S1 vs. S2 vs. S3) did not reveal variations in vigilance (RRT at S1 = 3.07 ± .07, RRT at S2 = 3.04 ± .07, RRT at S3 = 3.004 ± .1; F(2, 30.20) = .15; p = .86).
Recognition scores for learned items, computed as the number of correct recognitions minus the false alarms for distractors, was different between sessions (S1: 1.54 ± .40, S2: 5.57 ± .41, S3: 5.68 ± .53; F(2, 34.8) = 41.41, p < .001; Figure 1). Memory performance improved from baseline to after the night under CPAP (ΔS2–S1 = 4.02, p < .001; d = –1.69), then remained stable after three months (ΔS3–S1 = 4.14, p < .001, d = –2.12; ΔS3–S2 = –.12, p = .84, d = .12).
Recognition scores for lures (i.e., related “Theme” words) computed as the number of endorsed lures minus false alarms for distractors was different between sessions (S1: 2.78 ± .50, S2: 6.03 ± .52, S3: 6.14 ± .66; F(2, 35.43) = 18.52, p < .001). Lure acceptance increased from baseline to after the CPAP trial (ΔS2–S1 = 3.25, p < .001, d = –1.15), then remained stable after three months (ΔS3–S1 = 3.36, p < .001, d = –1.28; ΔS3–S2 = –.11, p = .88, d = 0).
Additional analyses conducted on participants› confidence in their responses (i.e., Remember, Know or Guess, see Figures 2, 3 and 4) showed that Remember responses for targets was different between sessions both for studied word (S1:.98 ± .50, S2: 3.45 ± .51, S3: 3.72 ± .66; F(2, 34.86) = 11.05, p < .001) and lures (S1: 1.39 ± .63, S2: 4.17 ± .65, S3: 4.54 ± .83; F(2, 36.28) = 9.95, p < .001). Recognition based on a clear memory of the presented word similarly increased from baseline to after the CPAP trial for studied words (ΔS2–S1 = 2.47, p < .001, d = –1.1) and lures (ΔS2–S1 = 2.78, p < .001, d = –.89), then remained stable at three months both for learned items (ΔS3–S1 = 2.74, p = .001, d = –1.08; ΔS3–S2 = .27, p = .70, d = –.24) and for lures (ΔS3–S1 = 3.15, p = .002, d = –1.13; ΔS3–S2 = .37, p = .66, d = –.39). No changes were found for familiarity-based (Know) or random (Guess) responses (all p’s > .05).
At the baseline session, recognition scores for learned items correlated with total sleep time (r = –.56, p = .006), sleep efficiency (r = –.5, p = .015) and total number of arousals (r = –.47, p = .03) for the prior night. When tested at the three-months session, recognition scores for lures correlated with PAP compliance (r = .81, p = .015).
No initial (1st and 2nd sessions S1 and S2) differences were found between the 12 participants who completed the 3 sessions of the study (CPAP compliant use) and the 11 who did not in recognition scores for learned items and lures. Similarly, vigilance (reciprocal reaction time) was similar between subgroups (see Table 1).
In the present study, we investigated PAP treatment-related effects on the storage and integration of information into verbal memory following immediate and delayed (three months) treatment schedules in individuals presenting with OSA. Our results evidence reversible OSA-related deficits in verbal memory both for the retrieval of learned items and for semantic generalization (i.e., acceptance of semantically related but non-learned items), with a significant improvement in performance after a single night under PAP treatment, persisting three months later under compliant treatment conditions. These findings are in line with previous studies relating neuropsychological impairment in OSA to sleep fragmentation and intermittent nocturnal hypoxia (Sankri-Tarbichi, 2012), reversible under CPAP treatment (Sforza & Roche, 2012), with a focus on verbal learning and memory abilities.
As compared to the non-treated baseline condition, the number of correctly recognized (i.e. really studied) items significantly increased after one night under PAP-treatment and persisted three months later, suggesting that compliant CPAP treatment reinforced overall episodic memory abilities. Previous reports likewise suggest that verbal memory impairments in OSA patients may be reversible under CPAP treatment (Rosenzweig et al., 2016; Sforza & Roche, 2012). Furthermore, endorsement of semantically related but not learned items (i.e., the lures) also increased after the initiation of PAP treatment and remained stable at three months. Considering these results, we propose that items never memorized but related to the learning lists’ theme (i.e., lures) have been more efficiently linked with associated representations in the pre-existing semantic network after sleep quality was restored by PAP. From another point of view, a prior study interpreted the higher production of false memories in patients with OSA than in healthy controls as indicative of a failure of the episodic component (i.e., temporal and spatial context) of verbal memory (Sarhane et al., 2014). Although production of false memory might indeed stem from episodic, contextual memory deficits (Daurat et al., 2008), it may also, in the DRM context, reflect the normal semantic categorization and generalization processes by which we integrate novel information into pre-existing knowledge stores, which is essential to daily cognitive functioning (Schacter, Guerin, & St Jacques, 2011). In this framework, memory distortions would result from evolutionarily based adaptive cognitive processes (Brainerd & Reyna, 2005; Schacter, 2001). Indeed, associative processes would provide the structure and organization that supports the general efficiency of memory performance, whereas gist-based processes would support the retention of themes and meanings, therewith facilitating generalization and abstraction. Gist-based memory mechanisms may additionally decrease the load of memory storage by forming condensed event records (i.e., the general idea) without the need to maintain many contextual details that might not need to be recalled later on. Remembering information based essentially on conceptual representations of the target event may thus occasionally lead to false memories, as missing details are reconstructed (Schacter, Guerin, & St Jacques, 2011).
Besides, the use of high-order cognitive abilities may allow individuals to set deliberate strategies to avoid the formation of false memories (Gallo, 2006). Indeed, another model for false memories is the activation-monitoring account (McDermott & Watson, 2001) that postulates two opposite processes. During the encoding phase, spontaneous and automatic activation of an associative network relating to the studied thematic list would occur. Conversely, at the recognition or recall phase, an efficient monitoring process would correctly associate the retrieval with the participant’s inherent thoughts and not with a previous presentation of the item within the studied list (Gallo, 2010; McDermott & Watson, 2001). Accordingly, the production of false memories could result from a greater activation of the critical item and/or from a defective source monitoring system. Accordingly, reducing the availability of attentional resources during encoding or retrieval using a divided attention procedure could mimic the effect of OSA in healthy participants (Sarhane & Daurat; 2019). However, this is somehow contradicted by evidence that some of the strongest false memory patterns reflect advanced cognitive handling, rather than deriving from impaired processing (Brainerd, Reyna, & Ceci, 2008; Brainerd, Reyna, & Zember, 2011). Indeed, whereas source monitoring errors were found more prevailing in cognitive immaturity conditions, e.g. in children (Brainerd & Reyna, 2005) and cognitively deficient adults (Law, Hawkins, & Craik 1998; Latour et al., 2014) notice the opposite pattern for false memory levels reported to be higher in adolescents than in children (e.g., Carneiro & Fernandez 2009), young adults than in adolescents (e.g., Lyons, Ghetti, & Cornoldi 2010), nondisabled than learning-disabled individuals (e.g., Weekes et al., 2007), non-autistic than autistic individuals (e.g., Hillier et al., 2007), and college students with higher versus lower SAT Reasoning Test scores (Brainerd et al., 2008). As compared to controls, patients with amnesia also exhibit reduced recognition scores both for correct and false-related items (Melo, Winocur, & Moscovitch, 1999; Ciaramelli et al., 2006, cited in De Brigard, 2014). This led some to name these « smart » false memories (Latour, Latour, & Brainerd, 2014), referring to the fact that they would result from a deep semantic processing (Brainer, Reyna, & Ceci, 2008).
Our results also showed that participants exhibit increased confidence in their memory recall (i.e., “remember” responses) after PAP treatment both for target and lure items. Together with increased recognition scores both for lures and targets, these results partly contradict the McCabe at al. (2009) proposal that decreased recall for learned items stems from an increase in false memories due to familiarity, or with the “Activation-Monitoring” assumption (McDermott & Watson, 2001) that a greater number of false memories would result from an inefficient source monitoring system. It has been proposed that patients with OSA have more difficulties consolidating the contextual and perceptual characteristics of the information (Barner et al., 2016). Patients with OSA would, therefore, be more likely to confuse different sources of information, leading to a higher production of false recognitions than controls (Sarhane et al., 2014; Sarhane & Daurat, 2017). However, our results show a concomitant increase in the production of “false” and “true” memories, which in the framework of these theories would paradoxically suggest a degradation in memory source after PAP treatment. Alternatively, if considering that efficient sleep benefits subsequent hippocampal activity and memory performance (Van Der Werf et al., 2009), and that the hippocampus plays an important role in binding information (Borders et al., 2017), it might also favor the induction of false memories using tasks such as the DRM paradigm, in which target and lure items are highly semantically related (Diekelmann, Born, & Wagner, 2010). Enhanced sleep quality (shown by diminished sleep fragmentation here) might thus facilitate the mechanisms by which themes are extracted from the learned lists, promoting automatic abstraction and generalization abilities (Diekelmann, Born & Wagner, 2010).
Accordingly, we found a correlation between PAP compliance over three months and acceptance score for semantically related lures, which may be interpreted as an increased tendency to abstract and retain the general theme following a PAP-related qualitative improvement of sleep. Prior studies already showed that the odds for normalization of verbal memory function after three months of CPAP treatment are related to compliance, being 7.9 times higher for optimal (average use > 6h per night) than poor (<2h per night) users (Zimmerman et al., 2006). In our population, average compliance rate was intermediate (5,1 ± 0.37 h per night). While some neurocognitive functions could benefit from PAP immediately after the beginning of the treatment, additional improvements in other neurocognitive domains might necessitate extended PAP treatment with good clinical compliance for patients with severe OSA (Lin et al., 2015). It was shown that one month of PAP treatment in patients with OSA leads to reduced daytime sleepiness and improved verbal episodic memory (Rosenzweig et al., 2016). This also corroborates our participants› subjective reports of a perceived improvement of memory skills and decreased sleepiness and fatigue at follow-up 3 months later.
Our study presents limitations that could be addressed in future research. First, the sample of participants at the three-month delay was reduced. This drop-out is representative of the known poor adherence and compliance to PAP treatment in part of the clinical population (Bakker et al., 2016). In this respect, highlighting rapid then enduring CPAP-related effects on cognitive processes would provide arguments to encourage the compliant use of PAP treatments. Second, this study was held in a sleep laboratory with recently diagnosed patients with moderate to severe OSA, who needed the rapid initiation of PAP treatment. It would have been ethically difficult to propose a sham PAP condition as a control, which leaves open the potential impact of motivational/placebo variables. Finally, one may wonder after the possibility of a repetition effect on performance, i.e. an improvement from one session to the other due to increased familiarity and practice on the DRM task. Although we did not run a control group to evaluate this potential repetition effect, we believe it unlikely as for the one hand, performance improvement only occurred from Session 1 (baseline) to Session 2 (PAP treatment) but did not further improve at Session 3 (3-months follow-up), and on the other hand, another study did not find any between-session improvement or strategic effects after repeated administration of the DRM test using different learning lists (Dehon, submitted).
To sum up, this study provides evidence for an immediate and persistent CPAP treatment-related improvement in both gist and item-specific verbal memory in OSA patients. This demonstrates a direct benefit of CPAP treatment on learning and memory generalization mechanisms and extent prior findings showing beneficial effects of CPAP treatment in various domains, from daytime functioning to higher-order cognitive functions.
This article has an online data supplement available on OSF database at https://osf.io/ra27m/.
O.B. is a Research Fellow at the FRS-FNRS (Fonds de la Recherche Scientifique), Belgium.
The authors have no competing interests to declare.
American Academy of Sleep Medicine (AASM). (2014). International classification of Sleep Disorders (ICSD), 3rd edition: Diagnostic and Coding Manual. Darien, Illinois: American Academy of Sleep Medicine.
Arndt, J. (2012). False Recollection: Empirical Findings and Their Theoretical Implications. Psychology of Learning and Motivation, 56, 81–124. DOI: https://doi.org/10.1016/B978-0-12-394393-4.00003-0
Babkoff, H., Caspy, T., & Mikulincer, M. (1991). Subjective sleepiness ratings: the effects of sleep deprivation, circadian rhythmicity and cognitive performance. Sleep, 14(6), 534–539. DOI: https://doi.org/10.1093/sleep/14.6.534
Bakker, J. P., Wang, R., Weng, J., Aloia, M. S., Toth, C., Morrical, M. G., Redline, S., et al. (2016). Motivational Enhancement for Increasing Adherence to CPAP: A Randomized Controlled Trial. Chest, 50(2), 337–345. DOI: https://doi.org/10.1016/j.chest.2016.03.019
Barner, C., Ngo, H. V. V., Diekelmann, S., Weeß, H. G., & Schlarb, A. A. (2016). Memory consolidation in fragmented sleep, N2 sleep spindles for verbal memory in patients with obstructive sleep apnea. Somnologie, 20(1), 37–46. DOI: https://doi.org/10.1007/s11818-016-0041-0
Basner, M., McGuire, S., Goel, N., Rao, H., & Dinges, D. F. (2015). A new likelihood ratio metric for the psychomotor vigilance test and its sensitivity to sleep loss. Journal of Sleep Research, 24(6), 702–713. DOI: https://doi.org/10.1111/jsr.12322
Borders, A. A., Aly, M., Parks, C. M., & Yonelinas, A. P. (2017). The hippocampus is particularly important for building associations across stimulus domains. Neuropsychologia, 99, 335–342. DOI: https://doi.org/10.1016/j.neuropsychologia.2017.03.032
Brainerd, C. J., & Reyna, V. F. (1998). Fuzzy Trace Theory and children’s false memories. Journal of Experimental Child Psychology, 71, 81–129. DOI: https://doi.org/10.1006/jecp.1998.2464
Brainerd, C. J., & Reyna, V. F. (2005). The science of false memory. New York: Oxford University Press. DOI: https://doi.org/10.1093/acprof:oso/9780195154054.001.0001
Brainerd, C. J., Reyna, V. F., & Ceci, S. J. (2008). Developmental Reversals in False Memory: A Review of Data and Theory. Psychological Bulletin, 134, 343–82. DOI: https://doi.org/10.1037/0033-2909.134.3.343
Brainerd, C. J., Reyna, V. F., & Zember, E. (2011). Theoretical and Forensic Implications of Developmental Studies of the DRM Illusion. Memory and Cognition, 39, 365–80. DOI: https://doi.org/10.3758/s13421-010-0043-2
Buchanan, P., & Grunstein, R. (2011). Positive Airway Pressure Treatment for Obstructive Sleep Apnea-Hypopnea Syndrome. In Kryger, M., Roth, T., & Dement, W. (Eds.), Principles and Practice of Sleep Medicine – 5th edition, 90–111. St. Louis: Elsevier Saunders. DOI: https://doi.org/10.1016/B978-1-4160-6645-3.00107-9
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193–213. DOI: https://doi.org/10.1016/0165-1781(89)90047-4
Canessa, N., Castronovo, V., Cappa, S. F., Aloia, M. S., Marelli, S., Falini, A., Ferini-Strambi, L., et al. (2011). Obstructive sleep apnea: Brain structural changes and neurocognitive function before and after treatment. American Journal of Respiratory Critical Care Medicine, 183(10), 1419–26. Retrieved from https://search-proquest-com.ezproxy.ulb.ac.be/docview/868210006?accountid=17194. DOI: https://doi.org/10.1164/rccm.201005-0693OC
Cardebat, D., Doyon, B., Puel, M., Goulet, P., & Joanette, Y. (1990). Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level. Acta Neurologica Belgica., 90(4), 207–17.
Carneiro, P., & Fernandez, A. (2009). Age Differences in the Rejection of False Memories: The Effects of Giving Warning Instructions and Slowing the Presentation Rate. Journal of Experimental Child Psychology, 105, 81–97. DOI: https://doi.org/10.1016/j.jecp.2009.09.004
Ciaramelli, E., Ghetti, S., Frattarelli, M., & Làdavas, E. (2006). When true memory availability promotes false memory: Evidence from confabulating patients. Neurophychologia, 44, 1866–1877. DOI: https://doi.org/10.1016/j.neuropsychologia.2006.02.008
Cipolli, C., Mazzetti, M., & Plazzi, G. (2013). Sleep-dependent memory consolidation in patients with sleep disorders. Sleep Medicine Review, 1(2), 91–103. DOI: https://doi.org/10.1016/j.smrv.2012.01.004
Csábi, E., Varszegi-Schulz, M., Janacsek, K., Malecek, N., & Nemeth, D. (2014). The Consolidation of Implicit Sequence Memory in Obstructive Sleep Apnea. PLoS One, 9, e109010. DOI: https://doi.org/10.1371/journal.pone.0109010
Darsaud, A., Dehon, H., Lahl, O., Sterpenich, V., Boly, M., Dang-Vu, T., Desseilles, M., Gais, S., Matarazzo, L., Peters, F., Schabus, M., Schmidt, C., Tinguely, G., Vandewalle, G., Luxen, A., Maquet, P., & Collette, F. (2011). Does sleep promote false memories? Journal of Cognitive Neuroscience, 23(1), 26–40. DOI: https://doi.org/10.1162/jocn.2010.21448
Daurat, A., Foret, J., Bret-Dibat, J. L., Fureix, C., & Tiberge, M. (2008). Spatial and temporal memories are affected by sleep fragmentation in obstructive sleep apnea syndrome. Journal of Clinical and Experimental Neuropsychology, 30(1), 91–101. DOI: https://doi.org/10.1080/13803390701236116
De Brigard, F. (2014). Is memory for remembering? Recollection as a form of episodic hypothetical thinking. Synthese, 191, 155–185. DOI: https://doi.org/10.1007/s11229-013-0247-7
Deacon, N. L., Jen, R., Li, Y., & Malhotra, A. (2016). Treatment of obstructive sleep apnea. Prospects for personalized combined modality therapy. Annals of the American Thoracic Society, 13(1), 101–108. DOI: https://doi.org/10.1513/AnnalsATS.201508-537FR
Deese, J. (1959a). Influence of inter-items associative strength upon immediate free recall. Psychological Reports, 5, 305–312. DOI: https://doi.org/10.2466/pr0.19184.108.40.2065
Dehon, H. (2006). Variations in processing resources and resistance to false memories in younger and older adults. Memory, 14(6), 692–711. DOI: https://doi.org/10.1080/09658210600648456
Dehon, H., & Brédart, S. (2004). False memories: Young and older adults think of semantic associates at the same rate, but young adults are more successful at source monitoring. Psychology and Aging, 19, 191–197. DOI: https://doi.org/10.1037/0882-79220.127.116.11
Deltour, J. J. (1993). Echelle de Vocabulaire Mill Hill de J. C. Raven: Adaptation française et normes comparées du Mill Hill et du Standard Progressive Matrices (PM 38). Braine-le-Château: Editions L’Application des techniques modernes.
Diekelmann, S., Born, J., & Wagner, U. (2010). Sleep enhances false memories depending on general memory performance. Behavioural Brain Research, 208, 425–429. DOI: https://doi.org/10.1016/j.bbr.2009.12.021
Ellis, B. W., Johns, M. W., Lancaster, R., Raptopoulos, P., Angelopoulos, N., & Priest, R. G. (1981). The St. Mary’s Hospital sleep questionnaire: a study of reliability. Sleep, 4(1), 93–97. DOI: https://doi.org/10.1093/sleep/4.1.93
Fraundorf, S. H., Hourihan, K. L., Peters, R. A., & Benjamin, A. S. (2019). Aging and recognition memory: a meta-analysis. Psychological Bulletin, 145, 339–371. DOI: https://doi.org/10.1037/bul0000185
Gallo, D. A. (2010). False memories and fantastic beliefs: 15 years of the DRM illusion. Memory and Cognition, 38(7), 833–848. DOI: https://doi.org/10.3758/MC.38.7.833
Gardiner, J. M., Ramponi, C., & Richardson-Klavehn, A. (1998). Experiences of remembering, knowing, and guessing. Consciousciousness and Cognition, 7(1), 1–26. DOI: https://doi.org/10.1006/ccog.1997.0321
Hillier, A., Campbell, H., Keillor, J., Phillips, N., & Beversdorf, D. Q. (2007). Decreased False Memory for Visually Presented Shapes and Symbols among Adults on the Autism Spectrum. Journal of Clinical and Experimental Neuropsychology, 29, 610–16. DOI: https://doi.org/10.1080/13803390600878760
Johns, M. W. (1991). A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep, 14(6), 540–545. DOI: https://doi.org/10.1093/sleep/14.6.540
Kloepfer, C., Riemann, D., Nofzinger, E. A., Feige, B., Unterrainer, J., O’Hara, R., & Sorichter, S. (2009). Memory before and after sleep in patients with moderate obstructive sleep apnea. Journal of Clinical Sleep Meicine, 5(6), 540–548. DOI: https://doi.org/10.5664/jcsm.27655
Krupp, L. B., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (1989). The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46(10), 1121–1123. DOI: https://doi.org/10.1001/archneur.1989.00520460115022
Laratta, C. R., Ayas, N. T., Povitz, M., & Pendharkar, S. R. (2017). Diagnosis and treatment of obstructive sleep apnea in adults. CMAJ: Canadian Medical Association journal = journal de l’Association médicale canadienne, 189(48), E1481–E1488. DOI: https://doi.org/10.1503/cmaj.170296
LaTour, K. A., LaTour, M. S., & Brainerd, C. (2014). Fuzzy Trace Theory and “Smart” False Memories: Implications for Advertising. Journal of Advertising, 43(1), 3–17. DOI: https://doi.org/10.1080/00913367.2013.811706
Law, S., Hawkins, S. A., & Craik, F. I. M. (1998). Repetition Induced Belief in the Elderly: Rehabilitating Age Related Memory Deficits. Journal of Consumer Research, 25(2), 91–107. DOI: https://doi.org/10.1086/209529
Lee, K. A., Hicks, G., & Nino-Murcia, G. (1991). Validity and Reliability of a Scale to Assess Fatigue. Psychiatry Research, 36(3), 291–298. DOI: https://doi.org/10.1016/0165-1781(91)90027-M
Lin, S. W., Chou, Y. T., Kao, K. C., Chuang, L. P., Yang, C. M., Hu, H. C., Chen, N. H., et al. (2015). Immediate and Long-term Neurocognitive Outcome in Patients with Obstructive Sleep Apnea Syndrome After Continuous Positive Airway Pressure Treatment. Indian Journal of Otolaryngology and Head & Neck Surgery, 67(1), 79–85. DOI: https://doi.org/10.1007/s12070-014-0777-4
Luz, G. P., Guimarães, T. M., Weaver, T. E., Nery, L. E., Silva, L. O., Badke, L., Bittencourt, L., et al. (2016). Impaired sustained attention and lapses are present in patients with mild obstructive sleep apnea. Sleep and Breathing, 20(2), 681–687. DOI: https://doi.org/10.1007/s11325-015-1279-7
Lyons, K. E., Ghetti, S., & Cornoldi, C. (2010). Age Differences in the Contribution of Recollection and Familiarity to False-Memory Formation: A New Paradigm to Examine Developmental Reversals. Developmental Science, 13, 355–362. DOI: https://doi.org/10.1111/j.1467-7687.2009.00889.x
Mairesse, O., Damen, V., Newell, J., Kornreich, C., Verbanck, P., & Neu, D. (2017). The Brugmann Fatigue Scale: An Analogue to the Epworth Sleepiness Scale to Measure Behavioural Rest Propensity. Behavioral Sleep Medicine, 24, 1–22. DOI: https://doi.org/10.1080/15402002.2017.1395336
McCabe, D. P., Roediger, H. L., McDaniel, M. A., & Balota, D. A. (2009). Aging reduces veridical remembering but increases false remembering: Neuropsychological test correlates of remember-know judgments. Neuropsychologia, 47, 2164–2173. DOI: https://doi.org/10.1016/j.neuropsychologia.2008.11.025
McDermott, K. B., & Watson, J. M. (2001). The rise and fall of false recall: The impact of presentation duration. Journal of Memory and Language, 45(1), 160176. DOI: https://doi.org/10.1006/jmla.2000.2771
Melo, B., Winocur, G., & Moscovitch, M. (1999). False recall and false recognition: An examination of the effects of selective and combined lesions to the medial temporal lobe/diencephalon and frontal lobe structures. Cognitive Neuropsychology, 16, 343–359. DOI: https://doi.org/10.1080/026432999380825
Nyenhuis, D. L., Stern, R. A., Yamamoto, C., Luchetta, T., & Arruda, J. E. (1997). Standardization and validation of the visual analog mood scales. The Clinical Neuropsychologist, 11, 407–415. DOI: https://doi.org/10.1080/13854049708400470
Pardilla-Delgado, E., & Payne, J. D. (2017). The impact of sleep on true and false memory across long delays. Neurobiology of Learning and Memory, 137, 123–133. DOI: https://doi.org/10.1016/j.nlm.2016.11.016
Pavwoski, P., & Shelgikar, A. V. (2017). Treatment options for obstructive sleep apnea. Neurology Clinical Practice., 7(1), 77–85. DOI: https://doi.org/10.1212/CPJ.0000000000000320
Payne, D. G., Elie, C. J., Blackwell, J. M., & Neuschatz, J. S. (1996). Memory illusions: Recalling, recognizing, and recollecting events that never occurred. Journal of Memory and Language, 35, 261–285. DOI: https://doi.org/10.1006/jmla.1996.0015
Rasch, B., & Born, J. (2013). About sleep’s role in memory. Physiological Reviews, 93(2), 681–766. DOI: https://doi.org/10.1152/physrev.00032.2012
Roediger, H. L., & McDermott, K. B. (1995). Creating false memories: Remembering words not presented in lists. Journal of Experimental Psychology Learning Memory and Cognition, 21, 803–814. DOI: https://doi.org/10.1037/0278-7318.104.22.1683
Rosenzweig, I., Glasser, M., Crum, W. R., Kempton, M. J., Milosevic, M., McMillan, A., Morrell, M. J., et al. (2016). Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure. EBioMedicine, 7, 221–9. DOI: https://doi.org/10.1016/j.ebiom.2016.03.020
Sankri-Tarbichi, A. G. (2012). Obstructive sleep apnea-hypopnea syndrome: etiology and diagnosis. Avicenna Journal of Medicine, 2, 3–8. DOI: https://doi.org/10.4103/2231-0770.94803
Sarhane, M., & Daurat, A. (2017). Obstructive sleep apnoea syndrome increases source-confusion errors: A pilot study. Journal of Neuropsychology, 11, 436–449. DOI: https://doi.org/10.1111/jnp.12101
Sarhane, M., & Daurat, A. (2019). False memories in obstructive sleep apnoea syndrome: evidence from the divided attention paradigm at encoding or retrieval. Memory, 27(3), 328–339. DOI: https://doi.org/10.1080/09658211.2018.1508592
Sarhane, M., Etcheverry, I., Tiberge, M., & Daurat, A. (2014). False memories in patients suffering from obstructive sleep apnoea syndrome (OSAS). Journal of Cognitive Psychology, 26(6), 662–669. DOI: https://doi.org/10.1080/20445911.2014.937812
Schacter, D. L., Guerin, S. A., & St Jacques, P. L. (2011). Memory distortion: An adaptive perspective. In: Schmolck, H. (Ed.), Trends in Cognitive Sciences, 15, 467–474. DOI: https://doi.org/10.1016/j.tics.2011.08.004
Schmitz, R., Dehon, H., & Peigneux, P. (2013). Lateralized processing of false memories and pseudoneglect in aging. Cortex, 49(5), 1314–1324. DOI: https://doi.org/10.1016/j.cortex.2012.06.005
Sejunaite, K., Lanza, C., & Riepe, M. W. (2019). Everyday Memory in Healthy Aging: Porous but Not Distorted. Frontiers in Aging Neuroscience, 11. DOI: https://doi.org/10.3389/fnagi.2019.00153
Sforza, E., & Roche, F. (2012). Sleep apnea syndrome and cognition. Frontiers in Neurology, 3, 1–7. DOI: https://doi.org/10.3389/fneur.2012.00087
Van Der Werf, Y., Altena, E., Schoonheim, M., Sanz-Arigita, E., Vis, J., De Rijke, W., & Van Someren, E. (2009). Sleep benefits subsequent hippocampal functioning. Nature Neuroscience, 12(2), 122–123. DOI: https://doi.org/10.1038/nn.2253
Wallace, A., & Bucks, R. S. (2013). Memory and obstructive sleep apnea: a meta-analysis. Sleep, 36, 203–220. DOI: https://doi.org/10.5665/sleep.2374
Weaver, T. E., & George, C. F. P. (2011). Cognition and Performance in Patients with Obstructive Sleep Apnea. In M. Kryger, T. Roth, & W. Dement (Eds.), Principles and Practice of Sleep Medicine – 5th edition, 1194–1205. St. Louis: Elsevier Saunders. DOI: https://doi.org/10.1016/B978-1-4160-6645-3.00104-3
Weekes, B. S., Hamilton, S., Oakhill, J. V., & Holliday, R. E. (2007). False Recollection in Children with Reading Comprehension Difficulties. Cognition, 106, 222–33. DOI: https://doi.org/10.1016/j.cognition.2007.01.005
Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370. DOI: https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
Zimmerman, M. E., Arnedt, J. T., Stanchina, M., Millman, R. P., & Aloia, M. S. (2006). Normalization of memory performance and positive airway pressure adherence in memory-impaired patients with obstructive sleep apnea. Chest, 130, 1772–1778. DOI: https://doi.org/10.1378/chest.130.6.1772